Improved variant calling accuracy by merging replicates in whole-exome sequencing studies.
vanderbilt.edu
Improved variant calling accuracy by merging replicates in whole-exome sequencing studies.
In large scale population-based whole-exome sequencing (WES) studies, there are some samples occasionally sequenced two or more times due to a variety of reasons. To investigate how to efficiently utilize these duplicated sequencing data, we conducted comprehensive evaluation of variant calling strategies. 92 samples subjected to WES twice were ...
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