Update on SORL1: Trafficking is Paramount, in Neurons and Microglia
Jan 17, 2025 · Yet, SORL1 gets plenty busy in microglia, as well, albeit on a different set of tasks, namely, supporting the lysosome. Previously, Young and colleagues found that while SORL1 …
After Immunotherapy, Amyloid Clearance Comes Down to Microglial …
Mar 14, 2025 · Microglia also took on distinct signatures depending on the extent of amyloid clearance in their neighborhood. For example, in cases of extensive plaque clearance, the cells upregulated …
A neurodegenerative cellular stress response linked to dark microglia ...
Jan 31, 2025 · In a tour de force of mechanistic studies, they linked dark microglia to the integrated stress response (ISR) pathway and identified several toxic lipid species as effectors of this gain-of …
TREM2: A Chill Pill for Neurons? | ALZFORUM
Apr 17, 2025 · The microglia then use a cell-specific ATP/ADP hydrolyzing ectoenzyme called CD39 to convert the ATP into AMP, which is then hydrolyzed to adenosine via CD73 receptors expressed by …
Protective Microglia Unmasked: They Act Like Regulatory T Cells
Nov 13, 2025 · This quadrupled CD28+ microglia and broadly calmed inflammation. Overall, microglia in these mice expressed half as much complement and interferon-response proteins as usual. They …
Microglia protect against age-associated brain pathologies
Jun 28, 2024 · Both papers agree that the lack of microglia in adult mice results in neurodegeneration, brain calcifications, and myelin abnormalities, phenotypes resembling CSF1R-related …
ACE Supercharges Microglia to Shrink Plaques | ALZFORUM
Jul 3, 2025 · Mouse microglia got a genetic tune-up. On 9 June in Nature Aging, researchers led by Warren G. Tourtellotte at Cedars-Sinai Medical Center in Los Angeles reported that expressing …
Moving Target: New Biology Casts TREM2 as a Shifty Mark
Apr 17, 2025 · For one, microglia hovering around plaques—the type that express the most TREM2—reportedly become desensitized to stimulation by TREM2 agonist antibodies. This …
Breaking the Spell: Checkpoint Inhibitors Help Microglia Snap Out of It
May 7, 2025 · All the things that define AD pathogenesis—the seeding and growth of Aβ plaques, withering of surrounding synapses, propagation of tau tangles, and infiltration of circulating immune …
A Unique Microglia Type Associated with Restricting ... - ALZFORUM
Jun 22, 2017 · There are points of real interest here, and it's potentially informative to take a step back and consider what's been detected using the elegant scRNA-Seq and computational modeling …