News

Gut6d
Nuclear Pirin promotes HCC by acting as a key inflammation-facilitating factor
Background Chronic inflammation and elevated reactive oxygen species are key contributors to hepatocellular carcinoma (HCC) ...
Gut6d
Adenoma detection and subsequent colorectal cancer risk: is the race really over?
A high adenoma detection rate (ADR) is vital for effective colorectal cancer (CRC) screening, but evidence suggests limited additional benefit beyond a certain threshold. In a pooled analysis of five ...
Gut6d
Small intestinal contrast ultrasound versus imaging and enteroscopy in Crohn’s disease
In patients with small intestinal Crohn’s disease (CD), there is a need for a simple, non-invasive test to reduce dependence on invasive procedures (eg, enteroscopy) and costly imaging (eg, MRI or CT ...
Gut12d
Non-invasive risk-based surveillance of hepatocellular carcinoma in patients with metabolic dysfunction-associated steatotic liver disease
Background Metabolic dysfunction-associated steatotic liver disease (MASLD) affects over 30% of the general population and is ...
Gut22d
Endoscopic mucosal and submucosal cutting for long benign oesophageal strictures
The treatment of long benign oesophageal strictures remains a clinical challenge. We present a novel endoscopic technique that involves visualising scar tissue using methylene blue-stained saline, ...
Gut26d
Cutting waste in endoscopy: a multicentre observational study in the German healthcare system
Background Endoscopic procedures are a notable source of medical waste, contributing significantly to environmental pollution ...
gut.bmj29d
Bacteria-metabolite butyrate boosts anti-PD1 efficacy in colorectal cancer patient-derived organoids through activating autologous tumour-infiltrating GNLY+CD8+ T cells | Gut
Figure 2. NaBu combined with anti-PD-1 modulates the cytotoxic subpopulation mainly through the GNLY + CD8 + T cell subset to improve immunotherapy. (A) Uniform manifold approximation and projection ...
gut.bmj2mon
Integrated multimodel analysis of intestinal inflammation exposes key molecular features of preclinical and clinical IBD | Gut
Background IBD is a chronic inflammatory condition driven by complex genetic and immune interactions, yet preclinical models often fail to fully recapitulate all aspects of the human disease. A ...
gut.bmj2mon
DUOX2 activation drives bacterial translocation and subclinical inflammation in IBD-associated dysbiosis | Gut
Background Inflammatory bowel diseases (IBDs) are characterised by dysbiosis and a leaky gut. The NADPH oxidase dual oxidase 2 (DUOX2) is upregulated in patients with IBD, yet its role in driving the ...
gut.bmj3mon
Longitudinal paired liver biopsies and transcriptome profiling in alcohol-associated hepatitis reveal dynamic changes in cellular senescence | Gut
Background and aims Alcohol-associated hepatitis (AH) is an acute form of alcohol-related liver disease (ALD) with high mortality rate. AH is histologically characterised by cellular processes, ...
gut.bmj3mon
GPR171 restrains intestinal inflammation by suppressing FABP5-mediated Th17 cell differentiation and lipid metabolism | Gut
Background GPR171 suppresses T cell immune responses involved in antitumour immunity, while its role in inflammatory bowel disease (IBD) pathogenesis remains unclear. Objective We aimed to investigate ...
gut.bmj5mon
Symptomatic reflux disease: the present, the past and the future
The worldwide incidence of GORD and its complications is increasing along with the exponentially increasing problem of obesity. Of particular concern is the relationship between central adiposity and ...