The excessive cosolute densities in the intracellular fluid create a physicochemical condition called macromolecular crowding (MMC). Intracellular MMC entropically maintains the biochemical ...

Sickness-induced sleep is a behavior conserved across species that promotes recovery from illness, yet the underlying mechanisms are poorly understood. Here, we show that interleukin-6-like cytokine ...

This theoretical study makes a useful contribution to our understanding of a subtype of type 2 diabetes – ketosis-prone diabetes mellitus (KPD) – with a potential impact on our broader understanding ...

Pipettes and Problem Solving is an initiative that teaches some of the skills needed to figure out why an experiment is producing unexpected results.

For the first time, a molecular mechanism is identified, for experimental acceleration and deceleration (rejuvenation) of sperm epigenetic aging.

These cells deploy complex cytoskeletal rearrangements to recognize and eliminate potential threats 3. Even in the steady state, myeloid cells constantly survey their surroundings for potential ...

In Type 1 diabetes (T1D), insulin-producing β-cells are killed by islet-infiltrating immune cells in a process called “insulitis”. T1D results in a critical requirement for exogenous insulin and ...

Live-cell microscopy routinely provides massive amount of time-lapse images of complex cellular systems under various physiological or therapeutic conditions. However, this wealth of data remains ...

Researchers have developed a computational tool that can pinpoint cause-and-effect relationships from large datasets of live-cell images, and illustrated its performance using a tumour-on-a-chip model ...

Structural studies reveal the mechanism by which the mRNA nuclear export machinery engages with nascent transcripts through interaction with the cap binding complex.

Pathogenic activating point mutations in the LRRK2 kinase cause autosomal-dominant familial Parkinsońs disease (PD). In cultured cells, mutant LRRK2 causes a deficit in de novo cilia formation and ...

Wong et al. (2019) used a sensory preconditioning protocol to examine how sensory and fear memories are integrated in the rat medial temporal lobe. In this protocol, rats integrate a sound-light ...