Nature

The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling

JAK2 belongs to the Janus family of cytoplasmic tyrosine kinases (JAK1–JAK3, TYK2) and functions as a crucial mediator of signaling for hematopoietic cytokines and hormones such as erythropoietin (Epo ...
Nature

Sticking together the Crumbs — an unexpected function for an old friend

Over the past 20 years, many factors that interact directly or indirectly with the short intracellular tail of Crumbs have been discovered, some of which seem to mediate the role of Crumbs in ...
JSTOR Daily

Cell-Cell Signaling in Xanthomonas campestris Involves an HD-GYP Domain Protein That Functions in Cyclic Di-GMP Turnover

This is a preview. Log in through your library . Abstract HD-GYP is a protein domain of unknown biochemical function implicated in bacterial signaling and regulation. In the plant pathogen Xanthomonas ...
JSTOR Daily

The Lateral Organ Boundaries Domain Transcription Factor LBD20 Functions in Fusarium Wilt Susceptibility and Jasmonate Signaling in Arabidopsis

The LATERAL ORGAN BOUNDARIES (LOB) DOMAIN (LBD) gene family encodes plant-specific transcriptional regulators functioning in organ development. In a screen of Arabidopsis (Arabidopsis thaliana) ...