Structurally, they look similar: MNK1 and MNK2 belong to the same enzyme family and are best known for regulating how cells make proteins. Their starring role in such a crucial cellular function has ...

Enzymes known as kinases play a critical role in cell growth, metabolism and signaling in a multitude of organisms across the tree of life—from algae to helminths to mammals. Now, scientists have ...

A new study reveals that the twin enzymes MNK1 and MNK2 play distinct roles in the brain, with one governing memory and the other social behavior.

Few effective treatments exist to treat neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS). 1 Existing treatments focus on ...

Protein kinase inhibitors represent a major advance in cancer treatment due to their ability to target the specific kinases involved in tumor growth and survival. More than 80 small-molecule protein ...

BACKGROUND: BCR-ABL tyrosine kinase inhibitors (TKIs) have been increasingly linked to pulmonary arterial hypertension (PAH) since 2009, although supporting evidence is limited. Our objective was to ...

Kinases are crucial to many signaling pathways, and when they don't work properly, the consequences can lead to problems, including cancer, immune diseases, and neurological disorders. But there are ...