Collaborative research by the University of Tokyo and RIKEN Center for Biosystems Dynamics Research has led to the development of a new method for simultaneously synthesizing all transfer RNA (tRNA) ...

Loss of TRMT10A led to a decrease in the levels of initiator methionine tRNA (tRNA iMet) and a specific glutamine tRNA (tRNA Gln). This reduction weakened the initiation of protein synthesis for ...

The synthesis of archaeosine involves multiple steps, with the first step introducing a preQ 0 base into tRNA via ArcTGT. In the second step, ArcS transfers an amino acid, lysine, to the preQ 0 base ...

RNA therapeutics target translation rather than DNA, aiming to correct shared protein production errors. By enabling cells to read through premature stop codons, engineered tRNAs could restore ...

A novel study uncovers how a subtle chemical tweak transforms the naturally occurring phytotoxin into a powerful molecular glue, 12-deoxyfusicoccin (12-dFC), that locks 14-3-3 proteins onto the ...

A new paper from the laboratory of David Liu, PhD, at the Broad Institute describes a genome-editing strategy that could result in a one-time treatment for multiple unrelated genetic diseases. The new ...

The researcher stresses that "this process is vital for the correct synthesis of proteins at the ribosome, the cell organelles where the translation of RNA into proteins takes place". Interestingly, ...

A novel tRNA fragment limits UV-driven photoageing by protecting collagen and mRNA stability. Discover the mechanism and its therapeutic potential. Read more.