New research suggests that balance and coordination problems in multiple sclerosis may begin when key brain cells slowly run ...

Many people with multiple sclerosis struggle with balance and coordination, and this study uncovers a hidden reason why.

Although the prevailing wisdom among neuroscientists is that Purkinje cells have just one primary dendrite that connects with a single climbing fiber from the brain stem, new research shows that ...

The cerebellum is instrumental in coordinating movement and refining motor control through intricate neuronal circuitry, with Purkinje cells serving as the central integrators of sensory inputs and ...

Purkinje cell drawing by Santiago Ramón y Cajal circa 1899. Scientists at the annual 2014 Society for Neuroscience meeting (November 14-19) in Washington D.C. presented unpublished research that links ...

MicroRNAs are essential for Purkinje cells to develop their characteristically elaborate dendritic arbors. When Scripps Research scientists temporarily turned off microRNA function during development, ...

Comparative transcriptomics between differentiating human pluripotent stem cells (hPSCs) and developing mouse neurons offers a powerful approach to compare genetic and epigenetic pathways in human and ...

Reduction in mitochondrial activity in multiple sclerosis contributes to Purkinje cell loss. Researchers at the University of California, Riverside (CA, USA) have demonstrated the role mitochondrial ...

Multiple sclerosis (MS) affects an estimated 2.3 million people worldwide. Approximately 80% of people with MS have inflammation in the cerebellum, the part of the brain that helps control movement ...

This Purkinje neuron was derived from patients with tuberous sclerosis and model properties of the disease at the cellular and molecular level. Sundberg and colleagues first created induced ...