Ligand-induced protein allostery plays a central role in modulating cellular signalling pathways. Here using the conserved cyclic nucleotide-binding domain of protein kinase A’s (PKA) regulatory ...
The dynamics of the RNA polymerase II (Pol II) backtracking process is poorly understood. Scientists have now built a Markov State Model from extensive molecular dynamics simulations to identify ...
To initiate transcription, the holoenzyme (RNA polymerase [RNAP] in complex with σ factor) loads the promoter DNA via the flexible loading gate created by the clamp and β-lobe, yet their roles in DNA ...
Representative structures for each of the four metastable states identified by our Markov State Model (MSM; S1-S4) and connected by the top one pathway from the pre-translocation state (S1) to the ...
This paper proposes a hidden state Markov model (HMM) that incorporates workers’ unobserved labor market attachment into the analysis of labor market dynamics. Unlike previous literature, which ...
Markov Models for disease progression are common in medical decision making (see references below). The parameters in a Markov model can be estimated by observing the time it takes patients in any ...
Journal of Applied Econometrics, Vol. 20, No. 2, Recent Developments in Business Cycle Analysis (2005), pp. 253-274 (22 pages) The objective of this paper is to evaluate the effectiveness of using a ...
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