Earlier methods to synthesize HAC relied on linking shorter DNA constructs into a larger chromosome within the cell in a process called multimerization. However, the genetic fragments tended to ...

The labs of Julian Sale and Jason Chin at the Medical Research Council (MRC) Laboratory of Molecular Biology in Cambridge, U.K., have created two new tools critical for rapid genome construction at ...

When constructing bacterial artificial chromosomes (BACs), researchers must verify that they successfully inserted their gene of interest. Because these insertions are large, scientists perform their ...

The Telomere-to-Telomere (T2T) consortium, co-led by UC Santa Cruz Genomics Institute Associate Director Karen Miga and National Institutes of Health Genomics Research Institute Senior Investigator ...

Bioinformaticians from Heinrich Heine University Düsseldorf (HHU) and the university in Linköping (Sweden) have established that the genes in bacterial genomes are arranged in a meaningful order. In ...

Agrobacterium tumefaciens magnified 15,000 times in an image captured earlier this year with a scanning electron microscope at Iowa State University's Roy J. Carver High Resolution Microscopy Facility ...

Cost-effective oligo system design schematic. Each synthetic oligo consists of two oligos (oligo-A and oligo-B), one forward primer (Primer-A), and two reverse primers (Primer-B and Primer-C). (A) ...

Synthetic biology is already rewriting life. In late 2023, scientists revealed yeast cells with half their genetic blueprint replaced by artificial DNA. It was a “watershed” moment in an 18-year-long ...