Looking to improve the quality of tools for discovering genomic regulatory regions, researchers at the National Institutes of Health combined Chromatin immunoprecipitation (ChIP) of hyper-acetylated ...

Tauopathies are classified by which tau isoform forms fibrils—those with three microtubule-binding domain repeats (3R), those with four (4R), or those with both. What drives one isoform to aggregate ...

Epigenetics is the study of acquired modifications in chromatin structure that emerge independently of any changes in the underlying DNA nucleotide sequence. Epigenetic alterations – comprising ...

Nucleosomes are barriers to RNA Polymerase II (Pol II) transcribing along gene bodies in eukaryotes. We found that a fragile “tailless nucleosome” could be generated to resolve the Pol II pausing ...

Bromodomain protein 4 (BRD4), a transcriptional regulator, plays a crucial role in autoimmunity, cancer, and inflammatory diseases. 1,2 Researchers found that BRD4 is a protein attached to acetylated ...

ROCHESTER, Minn. -- Mayo Clinic researchers have gained insights into the function of a member of a family of specialized proteins called histone chaperones. Using nuclear magnetic resonance (NMR) ...