One of the most iconic football rivalries could be at risk of going away for some time unless the schools can come to an agreement.

Preview the Oct. 18 matchup between the Notre Dame Fighting Irish and USC Trojans with predictions, odds, over/under, spread, betting lines and more.

The USC Trojans (5-1) hit the road to face the Notre Dame Fighting Irish (4-2) in a televised prime time college football tussle on Saturday, October 18. NBC Sports will broadcast the game live as this week’s primetime NBC matchup. Both NBC and Peacock will carry the game live from South Bend on Saturday, with kickoff time set for 7:30 p.m. ET.

What does the future hold for one of college football’s greatest rivalries? We asked a Notre Dame writer for his thoughts

No. 13 Notre Dame will turn to sophomore Joe Otting to take over at center for Saturday's showdown against No. 20 USC.

There are a lot of college football fans that declared Notre Dame's aspirations to avenge its 2025 national championship heartbreak dead after Week 2. The Fighting Irish lost both of their opening games to Miami and Texas A&M, yet clung to a Top 25 ranking throughout their winless start.

FOX college football analyst Joel Klatt is even more bullish on the Irish than AP voters, slotting them at No. 9 in his latest rankings.