While it’s certainly a positive that the reigning Offensive Player of the Year is back in their lineup, the club now has to navigate managing his injury. Part of that will likely be limited practice work and plenty of appearances for McCaffrey on the practice participation report as a result.

The San Francisco 49ers kicked off their Week 11 practices with a handful off injury issues keeping players from practicing in full. In total, nine players were either absent from the session or limited.

Speaking before Wednesday's practice and revealing their preliminary injury report, head coach Kyle Shanahan revealed both George Kittle (hamstring) and Nick Bosa (hip) would miss the opening session of their preparations for Sunday's clash with the Seattle Seahawks.