Sirens sounded in Israel as Iran launched dozens of ballistic missiles in retaliation for Israel's strikes on its nuclear facilities.

Iran and Israel targeted each other with airstrikes early on Saturday after Israel launched its biggest-ever offensive against its longtime foe in a bid to prevent it from developing a nuclear weapon.

President Trump joked that Iranian officials killed in Israel's airstrike clearly did not die of an illness, warning that Iran should have heeded his warning.

"Iran must make a deal, before there is nothing left, and save what was once known as the Iranian Empire," President Donald Trump said.

The attack was a stiff challenge for Israel’s air-defense system, which has intercepted projectiles fired from Gaza, Lebanon, Syria, Iraq, Yemen and Iran since the start of the war Oct. 7, 2023. They have ranged from short-range rockets to medium-range missiles to attack drones to ballistic missiles like those fired Friday night.

Israel obliterated top Iranian nuclear scientists with incredible precision, according to stunning new photos showing single apartments blown out of Tehran high-rises. Aftermath pictures of the

Footage of Iranian missiles hitting Israel in October 2024 has been falsely described online as showing Israeli strikes against Iran in June 2025.

Israel struck dozens of targets, including nuclear facilities, military sites and private residences, across Iran on Friday, killing a number of senior military commanders in what it called "Operation Rising Lion".

Crowds of demonstrators rallied in Tehran calling for retaliation after Israeli strikes on Iran and questioning whether the country should continue negotiations with the United States over a potential nuclear deal.

Israel attacked Iran early Friday with a barrage of airstrikes that took out top military officers and hit nuclear and missile sites, calling it just the beginning.

Israel’s military said Friday it had detected dozens of missiles launched from Iran and was working to intercept them. Residents were told to get into shelters and not leave without an official all-clear.

Israel’s historic strike on Iran revealed years of Mossad activity inside the country, including hidden weapons, drones and assassinations of nuclear officials.